English 版 (精华区)
发信人: yangs (Microsea永不止息), 信区: English
标 题: CD Player 的最新妙用
发信站: 哈工大紫丁香 (Sun Aug 31 22:04:23 2003)
CD Player Finds New Use as Molecular Detective
Scientists are using CD players to do a lot more than just play the latest top
-40 hits. A paper published online this week by the journal Organic and Biomol
ecular Chemistry describes a method of using the machines to detect molecules
in solution by monitoring their interactions with a modified CD. The researche
rs hope the innovation will lead to less expensive medical diagnostic tests.
Many laboratory tests rely on laser light to detect molecules. Recognizing tha
t CD players also utilize laser light to read information, James J. La Clair a
nd Michael D. Burkart of the University of California at San Diego decided to
take advantage of this relatively inexpensive set up. They first developed a p
rocedure to attach specific molecules to the face of a CD. These molecules are
chosen based on their ability to react with compounds of interest in samples
being tested. After the altered CD reacts with the sample solution, it is plac
ed in the player. The presence of extra molecules attached to the disc introdu
ces errors into the readout of the data. Comparing how the modified CD plays b
efore and after interacting with the sample can reveal the presence or absence
of the target molecules. "That抯 the novelty of this," Burkart says. "We are
actually using the error to get our effect."
Although the technique holds promise for medical testing, it cannot yet quanti
fy the amount of a particular molecule in a sample. Instead, Burkart hopes to
utilize it as a screening method in his chemistry lab, because compared to a $
100,000 protein chip reader, a CD player is a bargain. Plus, La Clair notes, "
how many people on this planet can actually hear a molecule attached to anothe
r molecule?" --Sarah Graham
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