Biology 版 (精华区)
发信人: zhili (北侠), 信区: Biology
标 题: mRNA很可能携带三维遗传信息(R Sb.)
发信站: 哈工大紫丁香 (Sat Nov 29 04:13:46 1997), 转信
From: shengy.bbs@bbs.sjtu.edu.cn (Sam)
Date: 12 Oct 1997 07:41:33 GMT
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发信人: wend (问道), 信区: Research
标 题: mRNA很可能携带三维遗传信息(R Sb.)
发信站: 生命玄机 (Thu Sep 25 21:58:54 1997) , 转信
Messenger RNA probably carries the three-dimenional
genetic information
张静 刘次全 来鲁华 白春礼 李维中 李任植 (In Chinese)
The forming mechanism of the three-dimensional
structures of protein, i.e. the mechanism of protein
folding, is a basic problem in molecular biology
which is still unsolved until now. In which a core
problem is whether there is three-dimensional genetic
information that decide the three-dimensional
structures of proteins. However, the
research on this field has not yet been reported.
Recently, we made a comparative study on the folded
structures of more than 70 nature messenger RNAs(mRNAs)
and the three-dimensional structures of the proteins
encoded by them, it has been found that there exist
marked corrsepondences between their featured structures
in the following aspects:
1. The number of the structural units.
....
2. Turning region.
...
3. The arrangement of structural elements in space.
...
All of these results suggest that the transfer of the
genetic information from mRNA to protein not only
is one-dimensional but also is three-dimensional.
That is, there exists the genetic information that
decide the three-dimensional structures of protein.
To a certain extent, we could say that the mRNA folding
determines the protein folding. Based on the results,
it would be possible to predict the three-dimensional
structures of proteins from the primary, secondary and
teriary structures of the mRNAs at a higher accuracy.
And more important is that a new clue has been provided
to uncover the "spatial coding" of the genetic information.
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